Pharmaceutical Excipients Market - Forecast(2021 - 2026)
Pharmaceutical excipients market is classified as organic and inorganic based on the type of pharmaceutical excipient products commercially available. Rise in healthcare expenditures, demand for new drug delivery systems along with need for enhanced medications are generating impetuous on pharmaceutical excipients market. Various pharmaceutical excipients are used for different drugs depending up on the complexity of the diseases. Another trend that drives the growth of this market is extensive research on the excipients that has given a better understanding of their functional benefits, thus their inclusion in the drug formulation has increased.
- New technologies related to the controlled release of small molecule drugs have been introduced in recent developments. Lubrizol LifeScience Polymers (LSP) has introduced its Pathway pharmaceuticalgrade thermoplastic polyurethane (TPU) excipients which offer controlled release in drug delivery systems and other applications. Lubrizol is now producing the materials under GMP conditions, which allows their use as excipients.
- EMD Millipore introduced Parteck SRP 80 which is a new polyvinyl alcohol (PVA)-based functional excipient. It is specifically designed for oral sustained-release formulations, particularly direct-compression processes. Manufacturers have promised its reliable performance profile and ability to facilitate the development of robust and cost-efficient manufacturing processes.
- MannKind Corporation has developed (AFREZZA) a non-injectable (orally inhaled) mealtime insulin therapy for improving glycemic control in adult patients with diabetes mellitus. MannKind is exploring the potential application of this technology for the pulmonary delivery of other drug substances. A novel excipient–fumaryl diketopiperazine (FDKP)–is inert and serves as a particle matrix (crystalline or amorphous) enhances effectiveness of the inhaled form of insulin. It carries the active drug and dissolves at the prevailing physiological pH in the lungs, where it is absorbed into the systemic circulation. Cipla tied with MannKind recently and will be responsible for obtaining regulatory approvals to distribute Afrezza in India, including approval from the Drug Controller General of India (DCGI).
- The material ‘Upsalite’ has been developed by company Disruptive Materials. It was first synthesized by researchers at Uppsala University; it is highly porous with a very large surface area and enables the controlled release of APIs including ibuprofen. It has been commercialized as a water-free, disordered, amorphous magnesium carbonate. It is thought that trapping of the drug molecules in the narrow pores of the material prevents them from adopting a poorly soluble, crystalline form.
- Pharmaceutical formulation experts are continuously working to improve the manufacturing process and product quality by using multi-functional excipients. It can help pharma manufacturing by improving flowability, enhancing compressibility, improving bioavailability, particle size distribution and reduced dust generation, etc. Evonik’s newly launched EUDRAGIT FS 100 is a solid version of existing EUDRAGIT FS 30 D. It allows pharmaceutical companies to use the polymer in various applications, such as hot melt extrusion, solvent spray-drying and solvent coating, which was impossible to achieve in prior decades where only the aqueous version was available. This multi-functionality approach allows overall new development possibilities within the pharmacy industry.
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